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Ashok Gupta Explains the Amygdala Retraining Program for ME/CFS/FM and Associated Illnesses

Ashok GuptaAshok Gupta’s experience with Chronic Fatigue Syndrome while in university and subsequent self-recovery gave him the insight and firsthand knowledge needed to develop his Amygdala Retraining™ Programme* that helps those with CFS, ME, Fibromyalgia, MCS and related conditions to re-set a chronic over-stimulation of the “fight or flight” center of the brain. He hopes to attract funding for a double-blind medical study and further research. He explains his theory below:

I have suffered from ‘chronic fatigue syndrome’ (ME/CFS) myself. Around 10 years ago, I developed it while studying at University.”

Since then, I have dedicated my life to finding an effective treatment for ME/CFS and associated conditions such as fibromyalgia, multiple chemical sensitivities, Gulf War Syndrome, etc. I have been completely well for years, and I successfully treat patients at my clinic in Harley Street in Central London (*; e-mail:

To help you understand the process that I believe has helped me and many others to improve, I will look at:

* An overview of The Amygdala Hypothesis – a “vicious cycle” that, once triggered by severe stressors in people with certain risk factors can perpetuate neurological overstimulation, physiological dysfunction, and many physical symptoms.

* An explanation of major symptoms in the context of this hypothesis.

* A brief summary of Amygdala Retraining™ concepts – how patients may break the vicious cycle by applying techniques that encourage the amygdala and associated brain structures to discontinue the hypothesized overstimulation – and pilot results observed at one year.

* Links to six free YouTube videos from the Retraining Program DVDs, which cover the entire hypothesis in depth.


My medical research seems to indicate that ME/CFS is a neurological condition, and may be caused by abnormalities in a brain structure called the “amygdala,” which is deep in the unconscious brain.

One of the amygdala’s roles is to protect the body from potential threats.

* Research on the amygdala has traditionally focused on physiological or emotional threats,

* Whereas recent research is showing that the amygdala is involved in protection mechanisms related to chemical and immunological threats as well.

This hypothesis serves as a potential unifying model for the various observations in patients. I published my hypothesis in the peer reviewed journal Medical Hypotheses in 2002. (It is available to read online here:

read the full article
read the appendix

*As of January 25, 2010, Planet Thrive is participating in an affiliate program for the Gupta Amygdala Retraining Programme™ after observing over 30 members of the Planet Thrive Gupta Support Group, who reported many benefits over several months time.

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  • Lori

    November 4, 2009 at 11:27 pm

    Dear Mr. Gupta,

    Thank you for your YouTube videos explaining a bit of your programme. And the interview on PlanetThrive. I am very intrigued.

    My story is very similar to yours though mine began in 1975 when I was 21 and a pre-medical student at Vanderbilt University. I became severely ill with all the symptoms of CFS. Unfortunately, at the time, no one had a clue what was wrong with me. I was diagnosed with CFS and Fibromyalgia in the early 90’s. What a relief to know I was not crazy.

    I have been dealing with this illness for 35 years and I believe I have tried just about everything and people have been telling me I just need to accept this life of severe fatigue and flu-like symptoms and foggy brain and pain.

    For the past year my husband has been out of work— previously he was an assistant professor at the The University of North Carolina in Asheville. Work is difficult to find here.

    I have been on disability since January 09.

    My question is: do you give any discounts to people in my situation? I am very interested in your programme.

    I look forward to hearing from you.

    Sincerely, Lori

  • earthwalker

    November 5, 2009 at 12:15 am

    Hi Lori,
    Ashok Gupta is not connected with Planet Thrive in any way except that we published his articles and interview here. If you’d like to correspond with him directly, please contact him through his website at or email him at Good luck!! Julie

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